Long-term survival in kidney transplant recipients with type 1 following islet transplantation
The researchers noted two significant positive results in their study.
At the one-year mark following the islet transplantation, there was an estimated 89.4% probability of graft survival.
Secondly, patients were estimated to have a 70.2% probability of achieving independence from insulin at one year.
Dr Mehdi Maanaoui, a nephrologist at the University of Lille, specialising in kidney and islet transplantation and lead author of the study, said: "Although islet transplantation has previously been shown to improve glycaemic control compared with conventional insulin therapy in recent clinical trials, little was known about its long-term impact on patient prognosis until now.
“These results are exciting and provide hope for people living with type 1 diabetes and kidney transplants.
"Islet transplantation could be a game-changer in the management of type 1 diabetes, and our research demonstrates a clear association between islet transplantation and a substantial increase in life expectancy.”
In 2021, there were estimated to be approximately 8.4 million individuals around the world with type 1 diabetes.
New diagnoses are expected to rise, with projections ranging from 13.5 to 17.4 million cases predicted by 2040.
It is estimated that around 30% of patients with type 1 diabetes will suffer from kidney failure.
These figures highlight the escalating public health challenge posed by type 1 diabetes and the urgent need for effective management and treatment strategies to address this increasing burden on healthcare systems worldwide.
Dr Maanaoui concluded: "Whilst further research is required to ensure the outcomes of islet transplantation begin to match the long-term success achieved with pancreas transplantation, we hope these findings help to increase patient access to islet transplantation.”
Professor Paul Johnson, Director of the DRWF Human Islet Isolation Facility at the Churchill Hospital, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), said: “Although several studies have previously shown the advantage of islet transplantation over conventional insulin treatment, this is one of the first studies to definitively demonstrate the impact of this advantage on the survival of kidney transplants in patients with type 1 diabetes.”
Find out more about type 1 diabetes
Read more about DRWF’s significant commitment to Islet Cell Research and Transplant both in the UK and around the world here
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